(Source: orangeis, via timetotimewarp)

316,374 notes

(Source: theroning, via fr4nk-the-bunny)

784 notes

witchyhellbroth:

pinenolanapple:

it takes 237 muscles to fake an orgasm but 15 to say “it’s called a clitoris and it’s right here”

#don’t ever fake an orgasm let them know they disappointed you

(Source: warmbloodedkiller, via fr4nk-the-bunny)

209,174 notes

jayjsupremacy:

themulattokat:

drinkingtheflood:

All my checks will…
bounce, bounce, bounce, bounce, bounce.

CRYING

Seagrams poppin’ in our refrigerator, $5 for 4 bottles and I save ‘em for later. I got: ramen on the left [left], pizza on the right [right], and a free month on netflix so we stay turnt up all night. 

jayjsupremacy:

themulattokat:

drinkingtheflood:

All my checks will…

bounce, bounce, bounce, bounce, bounce.

CRYING

Seagrams poppin’ in our refrigerator, $5 for 4 bottles and I save ‘em for later. I got: ramen on the left [left], pizza on the right [right], and a free month on netflix so we stay turnt up all night. 

(Source: tramampoline, via bonchat)

111,767 notes

WHEN ONE IS EXPECTING

imyourdestinymotherfucker:

Today, I bought this book (for my sister, lets clarify that now ‘cause the only way I’m going anywhere near sperm is if I fall into a vat of it):

image

BUT WAIT

THIS:

image

IS:

image

SOME:

image

OF THE BRILLIANT:

image

STUFF IT HAS IN IT:

image

(via cheerupsherlock)

82,288 notes

usmle1mikmonics:

diseasesinthreewords:
Posttranslational. The defective protein (a transmembrane conductance regulator) gets translated by mRNA and ribosomes. But the regular modifications that happen after translation fail (folding and glicosilation). Phenilalaline is the aminoacid deleted at position 508. Chromo 7 = Cystic 7ibrosis (turn F around) AR
Staph aureus. Sure, Pseudomonas is the more famous of the bacteria causing infections in CF patients. But it only leads the number of cases after age 10, before then, S. aureus is king.
Malabsorption. Very common to see malnutrition and poor growth and development. Hypoproteinemia and fat-soluble vitamin deficiencies are also classical.

cYSTIC FIBROSIS

N-acetylcysteine (cleaves disulfide bonds in mucus)  + antipseudomonal prophylaxis (tobramycin/azithromycin) 

Bronchiectasis, meconium ileus, nasal polyps, failure to thrive, \
Cystic fibrosis: presenting signs CF PANCREAS:
Chronic cough and wheezing
Failure to thrive
Pancreatic insufficiency (symptoms of malabsorption like steatorrhea)
Alkalosis and hypotonic dehydration
Neonatal intestinal obstruction (meconium ileus)/ Nasal polyps
Clubbing of fingers/ Chest radiograph with characteristic changes
Rectal prolapse
Electrolyte elevation in sweat, salty skin
Absence or congenital atresia of vas deferens

Sputum with Staph or Pseudomonas (mucoid)
“CF PANCREAS”
 Chronic respiratory diseases occur*
 Failure to thrive, poor weight gain
 Pancreatic exocrine and endocrine insufficiency, Pulmozyme as treatment
 Autosomal recessive inheritance, metabolic Alkalosis
 Neonatal intestinal obstruction, meconium ileus, intussusception, volvulus
 Clubbing of fingers, Cholestasis, biliary Cirrhosis, …**
 Rectal prolapse
 Electrolyte excess in sweat like sweat Na+ and Cl-
 Azoospermia and infertility
 Staph aureus and pSeudomonas in sputum, Salty sweat

usmle1mikmonics:

diseasesinthreewords:

  1. Posttranslational. The defective protein (a transmembrane conductance regulator) gets translated by mRNA and ribosomes. But the regular modifications that happen after translation fail (folding and glicosilation). Phenilalaline is the aminoacid deleted at position 508. Chromo 7 = Cystic 7ibrosis (turn F around) AR
  2. Staph aureus. Sure, Pseudomonas is the more famous of the bacteria causing infections in CF patients. But it only leads the number of cases after age 10, before then, S. aureus is king.
  3. Malabsorption. Very common to see malnutrition and poor growth and development. Hypoproteinemia and fat-soluble vitamin deficiencies are also classical.
  4. cYSTIC FIBROSISimage

  5. N-acetylcysteine (cleaves disulfide bonds in mucus)  + antipseudomonal prophylaxis (tobramycin/azithromycin) 

Bronchiectasis, meconium ileus, nasal polyps, failure to thrive, \

Cystic fibrosis: presenting signs CF PANCREAS:

Chronic cough and wheezing

Failure to thrive

Pancreatic insufficiency (symptoms of malabsorption like steatorrhea)

Alkalosis and hypotonic dehydration

Neonatal intestinal obstruction (meconium ileus)/ Nasal polyps

Clubbing of fingers/ Chest radiograph with characteristic changes

Rectal prolapse

Electrolyte elevation in sweat, salty skin

Absence or congenital atresia of vas deferens

Sputum with Staph or Pseudomonas (mucoid)

CF PANCREAS

  •  Chronic respiratory diseases occur*
  •  Failure to thrive, poor weight gain
  •  Pancreatic exocrine and endocrine insufficiency, Pulmozyme as treatment
  •  Autosomal recessive inheritance, metabolic Alkalosis
  •  Neonatal intestinal obstruction, meconium ileus, intussusception, volvulus
  •  Clubbing of fingers, Cholestasis, biliary Cirrhosis, …**
  •  Rectal prolapse
  •  Electrolyte excess in sweat like sweat Na+ and Cl-
  •  Azoospermia and infertility
  •  Staph aureus and pSeudomonas in sputum, Salty sweat

(via medicalexamination)

92 notes

(Source: womenshealthandcare.com, via ragincontagion)

79 notes

gymleaderkyle:

if youre in a heterosexual relationship like who gets to be the woman and who gets to be the other woman?

(via queerly---beloved)

15,922 notes

(Source: poreless, via thisurge)

4,980 notes

15-year-old me: MOM I'm practically an ADULT ugggh you never let me do ANYTHING in olden times i could get MARRIED *eye roll into another dimension*
me now: for my birthday i want food and to stay on your health insurance
71,638 notes

(Source: asapscience, via thisurge)

955 notes

blackbarmitzvahs:

Can you imagine the conversation though?
Queen: I’m going
Chief of Staff: But, Your Majesty, the security risks…
Queen: I’m going I want cake 
Chief of Staff:
Queen: 
Chief of Staff: 
Queen: I want cake

blackbarmitzvahs:

Can you imagine the conversation though?

Queen: I’m going

Chief of Staff: But, Your Majesty, the security risks…

Queen: I’m going I want cake 

Chief of Staff:

Queen: 

Chief of Staff: 

Queen: I want cake

(Source: youknowyourebritishwhen, via cheerupsherlock)

413,186 notes

brainbubblegum:

kyarumii:

Sure. Let’s just go down to the Anus Hole and get some ice cream

Hey, man. Don’t diss. Anushole makes the most unbelievable chocolate soft serve in town.

(via rozzdog)

23,983 notes

penis-hilton:

the challenge

penis-hilton:

the challenge

(Source: wolfchoir, via rozzdog)

40,705 notes

adventuretitan:

m-e-s-t-i-z-a:

housewifeswag:

gayspicy:

im so fucked up over the fact that some countries have free college

and free healthcare 

Kinda like their government acknowledges that those are rights not privileges

ooooh boy you have no idea how close all these countries are to losing these things… unfortunately…

because middle upper class bigwigs thinking that theyre dangerous or unnecessary

272,047 notes